PDRN (Polydeoxyribonucleotide) is the hottest skincare ingredient to emerge from Korea in 2025. These DNA fragments derived from salmon sperm cells are prized for their remarkable regenerative properties.
Once an exclusive Hollywood injectable treatment, PDRN is now available in many Korean skincare products including serums, ampoules, moisturizers, and face masks. The ingredient went viral on social media with celebrity fans like Kim Kardashian and Jennifer Aniston, who reportedly love in-office PDRN skin treatments.
What makes PDRN remarkable is its ability to interact directly with your skin cells, promoting natural healing processes at a cellular level—not just on the surface.
How It Works
PDRN works by activating the A2A adenosine receptors, which play a crucial role in tissue repair and anti-inflammatory responses. Unlike traditional ingredients that work primarily on the skin's surface, PDRN penetrates deeper, working at a cellular level to promote genuine skin regeneration and repair.
The compound stimulates fibroblast proliferation (the cells that produce collagen), accelerates wound healing, and reduces inflammation. This medical-grade approach to skincare is why PDRN was originally used in hospitals for burn victims and post-surgical recovery before entering the beauty world.
Korean brand Rejuran pioneered PDRN in skin boosters (dermal injections) that dermatologists use to improve skin elasticity, repair damage, and reduce fine lines. These treatments remain incredibly popular in Korea today.
Types of PDRN
1st Gen: Salmon PDRN
Original formula derived from salmon DNA, considered most potent
2nd Gen: Plant PDRN
Vegan alternative from centella, ginseng, or rice—similar but not identical benefits
3rd Gen: Microbial PDRN
Lab-cultured PDRN, sustainable and consistent quality
Benefits
Best For
How To Use
Cautions
- •Patch test if you have seafood allergies (salmon-derived)
- •Choose plant-based PDRN if vegan or allergic
- •May cause mild tingling initially
- •Avoid if pregnant or breastfeeding (limited research)
- •Store in cool, dark place to maintain efficacy
